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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f99fa65c1c5bf1b23e7444c481bd10ba2c43a398a5a4f57577c3ee322b368a2' 
  AND token = 'D8KWcy0PtpIdVDyZa7ydW4pHVVxEA+Y0wqFgZ4Fahm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}