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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48fd0801f100d90c77eee8a0b611af01c29168d49cc5f8baf2c3da6d426ed301' 
  AND token = 'hD0Ey5jarcsBbX8V4p1FN8lqvcJIOUtAHOg6vb6fI7k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}