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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f83f59d0c7fdf7ced6be31eaa43d28152a79e5ee1a214422227b7fcb1daefc1' 
  AND token = 'JJHg5v3cBVJrwu1VrEe5uPzZ2Q56rdsseP6ETZW+Vho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}