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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9280d2e38b836f3acaa2df9b04b764537c2017a1afd06520003ce1f9f90ec017' 
  AND token = '0EN0zV2UB5Ex19gq1D1jzdigY719xa3ZC5DBmyj2ccM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}