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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '324148e3e256eef9f98bce33c358629deec6607e7498b716f1fdc875808e6a1f' 
  AND token = 'S7eKCYhAl4duRE9Xp4Ozf+Icu72ifGC//9FVx/lEric=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}