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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e0e4fdf544a4b60ec0b4be5050cf03e2d40a6862824fb0d9c0d7ccec6814379' 
  AND token = 'KhSaZbwhTTp1c0INFHY2kQjiU8hqQzerRv1NL8fDXH4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}