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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2354c4ff5e96ac3b65bbf617c9b0f916d34c993fd3d2094f53f8c749fac38da' 
  AND token = 'u6+QSEFvv1MkoN9wCQelqAKV17HU7qsLbPzAGGaaMPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}