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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d53aaa25b23b2c41e35c396a43843d1b425905901c1064794bbc361b41ba8fc' 
  AND token = 'T+8SYDB4XEbavp0Lgimrqv7bTB2ALKj+NJOB2ZIeMo0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}