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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d43ee03eb06f2e8950935ac00469ac862a9a26503ee526aa042aa44a6d57bb1' 
  AND token = 'EiXX9KP5TToyRBkmWMQUtu/oUBvrL8j1U7uHbjVU1HI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}