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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b549ba70d151f625e698668a9545c4b4042dc97a4b84d20f90516d8af3b73f59' 
  AND token = 'Zl7Ff5SEXCDpC1FvOd6nw3qqUVG8b+poIPanA6idLg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}