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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f4a0e7f6bf33091c0f37a33da8b30feb9d4d32f4f3fee9b261d606bcc167e0a' 
  AND token = 'GuaXcNZKZ3lw9aGp2kch8qiQFh/TcZ+GEqeUeTThe8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}