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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7841bc1f86d1193c9b9db1f25495de0ac242e140526e5e71b8e015c426c0d195' 
  AND token = 'GusvDlps2oCimQETO0i+VBuPCIWI1NC2qhbdHNJ0pD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}