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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '76a4220cfdb62fe37ed5b222fc1f8857e4613aa3b36d634ff00f35428bbd1e51' 
  AND token = 'zH1OPIS/P8KxzPc+m7YWa58hQY00ICulskU3LTz8CNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}