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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f75d1d250471862a2d1700edef04a4946fb2503b06405b7f9b948628b60aa51' 
  AND token = 'ZDkWu4TFZBBf60AwlgtWO35oolT/VzhXbItJ3XpU5Gg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}