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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f410851209c4f3b56025bc0c241fb35b6d202f86be1dc5035d5f964d7f8dcf6' 
  AND token = 'CpG22DXId9/5wHSWnz+fuN54Y76NSggUrPUF7mqkbCA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}