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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acb4a9396a0339ff22f20d918a3b7a84fd379a7c355b38d0280f3a3d803d144d' 
  AND token = 'n8Ney3OrVG4SN2GJUbUKS+PQiW8zyvwDBtEKyLpAhf8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}