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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ed161e91aa98f1a2ffde600f54bb485f99da997f14f6457587a181c9ff029bb' 
  AND token = 'JF8A/SA85h2TqISutI8Wrs0XuN4WDHkhykXlWVf4C4w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}