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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ca17342b71d5916da06335df16a01c43a68721f7b6f641d9c9c07e39864dee6' 
  AND token = '1gwuLj0OSMUCGnKPcqbk+FT16OV2SD6ILGW3Ecgw4fw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}