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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2a46f08d5554a039da5e898badb1668673cdc54b1954d0005de353c6c69ffc4' 
  AND token = 'Jv1FH08Q6hsUI5PYVQu+QHYKF2sSQuv+hCCsYdeZ7ik=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}