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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2fe705d9c3b0a9cf46aaab78c8aa94f6ec0f87599e1d4f0e612797569d1d2ff6' 
  AND token = 'KiUUp58/jJe1f9H+mx1ZrsAGJsUXjIhFPyaKZKO9TgQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}