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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5af2a9faa9fc2c89ca40b3fde8615444d589764b2d4320b71c2e18e762deee29' 
  AND token = 'NvXbEAON5qgH8wwoJm5Ai5NXQAawkxLHBndeY/Hy+ts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}