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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a41f9b15bdee9eeb3edc9f6b1a0db4bb4a895c9894e1100df415623aa1267e0d' 
  AND token = 'EhTtBD/tOQD8+hbC+ppywRzQ5+g/as64xtBKJEiEX/k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}