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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d4cdbd99eb3dbc0815754650a1a9ce172b0fb105b82aa49f61bae662cbc0865' 
  AND token = '+3YlawOm2uxTAe026EBkLZw8pUlkXhWcwMdK2WZ3qaM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}