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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e621a2abdffc40c4b9bab4698c93ad02491b87234dd2b016ad19e0fdc7e58d05' 
  AND token = 'EgUPs5Aq7i7PVjhR67NayJyJDAMCCvCdHOBIhhuF0LU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}