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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af46e379888bee3934eabdd29a77ddfeb94f3ee37a65aa7211dda1fafa150fd5' 
  AND token = 'Xe0Nf/6y5BGZPSSwgL5WRZhx3EAG4ffcjqigC9kGW6M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}