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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bc782e2c19d32e4297f842c2487491660a80980fb935df8bd029fc13438bb308' 
  AND token = 'cs8WH4Ii/6d1I2sXu29FgBbCklkhLLNfyF/oqAp+z5E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}