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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a7781256e6d84d9adaef05207e0630b30c666c3d4649654fea4e05634ea1d298' 
  AND token = 'jSPIZL79EqAJw5jHU86pIWMFqpWjEY0XnAtA0w5GpIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}