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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b2a8878be31c19f4512d0b4dfa98f44fed95c2c563950032f2697fe26dca2c5' 
  AND token = 'PPq1FK3lDA2wuCM5uCzuOUEmZ5vIXmYNpzfYkIEw4bk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}