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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef8d2f43808410741c2784b736a90edc5d4672f377d6cd716598d0f0cf3e8721' 
  AND token = 'YeyyRqtpVy2bvQr3uKAI85Zqn2zEl3eO6dkVth1Yi44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}