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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4758541392ee9f350e989f8fef94b44e4cf67e5777aba22e6c5f4442f4129cf8' 
  AND token = 'Z8h1oHZCswO2jk0iojTTn1giXYgMaNz4tpulvqcYul4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}