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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64bd80e8a1977b73a2c4b0148f721d44f4394c8f56a9f028b2d8f88352057550' 
  AND token = 'KxWxtStz/aeVBE+l/E8VbnvzNvje3oGxCG/Erdm4Lnc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}