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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '297d1fa616f14ffc376789ab5c1f1bdc2bab29c56afb2adb385ee6e084372032' 
  AND token = '3+bC2LsHoc5wI+h0C5QfPoIiJKwwFEvx6hCx+qmUwLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}