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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a0a588a9f78fb6897fd31ef1a603440fdc6b4e2e09c3bbb77683a78f70a4a442' 
  AND token = 'FtiETZ+VMe2AGpx4fNLTIeRd2ciw4uDiWN4PXKdidsM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}