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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52e7e8e3f39bd3befb23df51a321c03f8e4af3aa189ac1ca04863171944efff8' 
  AND token = 'mHrDMSo+Q2f1MRHB4WYD9B7XXxivuTwk/IiDFrt4rDM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}