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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12f8552d42e7e525e9945df65162790b0bc0f587d6bc8af534f9607ffa7254dc' 
  AND token = 'kdUMg/5VSPPEosHhnl3FRt1OZxEf1rf3oZs+qzbdtUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}