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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c55b953406eb33d52d1d319a5f96cc7baf49be1cc56940fddf3039872f6b2b65' 
  AND token = 'W7c/UPLD/zjsNX9ZxtWbMV+mywSHP70lSc3x2vZ0pks=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}