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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5258d1690d2dce5aa9a06767783041cbb18511651f70b72913cce8f3401cc135' 
  AND token = 'AWqIrkHQHF/+dKP46KLl6er/2AaRQrDtqCCCYEuJpEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}