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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '900a20fd8cc704909f3e0c7f10581a38dc7b527d88b4f2b51175bd11c003c52a' 
  AND token = '+V+656Iet76JQgTUUxu5WIzQHR0sYcylh/A5LhA74EE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}