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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ede8c3dcf11f0b731b917b16160c8c0c4936ab0d4569593c1e4651840c2e1b02' 
  AND token = 't4WHXZGkwom/zoSVfawmBsFHeQHHzB3yXBRuN8SbkEs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}