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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22648ec6d07e720fdef2f0b2aad2cba65ad07ee8178158e699bab931f493d421' 
  AND token = 'gcbCpPKtvEtl2vQvDG0kzzEkiPE901hc49dHS1Ghby4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}