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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781b45cf832a262a1e678c351d5480dd39a768582fbb8346e4be96632f45716a' 
  AND token = 'oEyCi4HYyh9Bem+NQhkPGEI5OW307mTU5+W50eEZje8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}