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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d0409ee7bc38fcc01538c16e8d677e67e051e7b97a18afff767c074e59e39c' 
  AND token = 'uxCoTaZIAe85OkmtUXmT2CR6LkS3uGiOTSDTHA+5Xrg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}