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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '266d48db6a5d319ada437ab76eadf5043d2df792afe8fd5bbd02467ac7a49b38' 
  AND token = 'P/KfatfI03uTw+TsH/XcfgaQlwUXW0AuR1HQdgzI1Pk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}