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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd3e00a7e61449ed4711deb36fce60d12b46eb60aa988b1389116540b1134c821' 
  AND token = 'wRfkHOfLTXxM4i65yXzsjD/1HemPnTNoo8qfvOnUlKk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}