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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21146a111fac18a0949eaf711d9d2f12f778b1ddaac04992c8e263b6ce6af728' 
  AND token = 'ZgbeHrPWAR3rKKFlRvjKkc4aw6Eea2eOPKaT9SFQfzo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}