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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e3cbf3c7fa008f3c75b80b030c0700ca1c2bba0a741dda61e1b3b452c109846' 
  AND token = 'TXTwYZNO2xDo4nlAJFdZGkRBRqAYsmldjOn3bVKzuf8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}