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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78bd0c1c90cdc79ff2c472dae632c0297935b00f5cff8b82ca45df38d3c02f0c' 
  AND token = 'E8RwGWPVXRnA9CgHfwOEzy7OazX8JOeLi0jN7qkDj2c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}