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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '429cdb5c0a3e18ad8a792e74e858f96ae5e7f842cbf4a2b821c1e3f8bf78e357' 
  AND token = 'SSDKAj0FhC+b2LWROzz6HS2ruWdHpVwCbPmWwshb5NU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}