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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '121c96e291ff0e66fc380b718bb4bcd4a250778fca251414e352d39ea8e445c6' 
  AND token = 'IU9w20FLq9B0BMl7yryxQZjzMf1w03LL369iwMEHiUY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}