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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c563aff0a28228b62aa7c0ee3e388cb1860cc3928d820a3349e770881735e4d5' 
  AND token = 'YI7qCYqfFHpe5S7t5i1A+AQT2VXHKBS0ZKzhUJpuYO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}